Colorectal Cancer Gene Panel

Genetic test for KRAS/NRAS mutations to predict response to EGFR inhibitor therapies.

Test description

Specific activating mutations in KRAS and NRAS genes indicate there is likely to be reduced response to EGFR inhibitor therapy. Lack of activating mutations defines eligibility for accessing anti-EGFR therapies under the Pharmaceutical Benefits Scheme (PBS).

Test information

Test name

Colorectal cancer solid tumour panel

Clinical indication

Testing of metastatic colorectal cancer tumour tissue to determine the eligibility for access to cetuximab or panitumumab under the Pharmaceutical Benefits Scheme (PBS).

Gene(s)

KRAS, NRAS, BRAF, PIK3CA, EGFR

Method

NGS Oncomine Precision Assay

Turn around time

1 week from receipt of sample

Medicare eligibility

73338 Criteria apply – dependent on tumour type and stage

Price

If not MBS eligible, please contact 1800 822 999 for pricing details

Test request form

Standard pathology request form

Sample type

FFPE Tumour Tissue

Collection type
Special instructions

6 x 5 micron slides plus 1 x H&E stained slide required